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KMID : 0366220060410020129
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Korean Journal of Hematology
2006 Volume.41 No. 2 p.129 ~ p.133
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CD56+ T-cell Prolymphocytic Leukemia Showing a High Expression Level of TCL1 Oncogene: A Case Report with a Review of the Literature
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Yun Hyeong-Kee
Cho Duck
Shin Myung-Geun
Kim Hye-Ran
Park Ji-Young
Kee Seung-Jung
Kim Young-Hyu
Shin Jong-Hee
Suh Soon-Pal
Ryang Dong-Wook
Kim Hyeoung-Joon
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Abstract
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T-cell prolymphocytic leukemia (T-PLL) is a rare mature post-thymic T-cell malignancy with infiltration to the blood, bone marrow, lymph node, liver, spleen and skin; this disease has a poor prognosis and an aggressive clinical course. We report here on a case of CD56+ T-PLL that was diagnosed by hematological examination, immunophenotyping and molecular studies including determining the TCL1 expression by using reverse-transcriptase polymerase chain reaction (RT-PCR), and direct sequencing of the RT-PCR product.
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KEYWORD
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T-cell Prolymphocytic Leukemia, TCL1, CD56
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